Role of aldosterone availability in preeclampsia

Escher, Geneviève; Mohaupt, Markus (2007). Role of aldosterone availability in preeclampsia. Molecular aspects of medicine, 28(2), pp. 245-54. Amsterdam: Elsevier 10.1016/j.mam.2007.03.002

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Preeclampsia is a hypertensive disorder unique to pregnancy and remains the leading cause of maternal and fetal morbidity and mortality. Despite active research, the etiology of this disease remains still an enigma. There is increasing evidence that a combination of several factors is responsible for the development of preeclampsia. In this review, we discuss the role of aldosterone in the regulation of body fluid in pregnancy and preeclampsia. Aldosterone is produced by the enzyme aldosterone synthase and competes with cortisol and progesterone for the mineralocorticoid receptor, thus affecting sodium reabsorption and maternal volume expansion. Aldosterone seems to play a pivotal role in controlling blood pressure during pregnancy and to contribute to the well-being of the mother-to-be. Novel findings in understanding the underlying causes of preeclampsia provide a rationale for future novel prophylactic and therapeutic interventions in the treatment of this pregnancy-associated disease.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Escher, Geneviève and Mohaupt, Markus

ISSN:

0098-2997

ISBN:

17512581

Publisher:

Elsevier

Language:

English

Submitter:

Markus Georg Mohaupt

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1016/j.mam.2007.03.002

PubMed ID:

17512581

Web of Science ID:

000247975400006

URI:

https://boris.unibe.ch/id/eprint/23030 (FactScience: 38665)

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