Upregulation of c-Myc may contribute to the pathogenesis of canine pemphigus vulgaris

Williamson, Lina; Suter, Maja M; Olivry, Thierry; Wyder, Marianne; Müller, Eliane J (2007). Upregulation of c-Myc may contribute to the pathogenesis of canine pemphigus vulgaris. Veterinary dermatology, 18(1), pp. 12-17. Oxford: Blackwell Science 10.1111/j.1365-3164.2007.00561.x

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The pathomechanism in human pemphigus vulgaris (PV) has recently been described to rely on generalized c-Myc upregulation in skin and oral mucosa followed by hyperproliferation. Here we assessed whether dogs suffering from PV present the same pathological changes as described for human patients with PV. Using immunofluorescence analysis on patients' biopsy samples, we observed marked nuclear c-Myc accumulation in all layers of the epidermis and oral mucosa in all (3/3) dogs analysed. In addition, c-Myc upregulation was accompanied by an increased number of proliferating Ki67-positive cells. These molecular changes were further paralleled by deregulated expression of wound healing and terminal differentiation markers as observed in human PV. Together these findings suggest a common pathomechanism for both species which is of particular relevance in the light of the recently discussed novel therapeutic strategies aiming at targeting PV antibody-induced signalling cascades.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology

UniBE Contributor:

Williamson Ramirez, Lina; Suter, Maja and Müller, Eliane Jasmine

ISSN:

0959-4493

Publisher:

Blackwell Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

13 Dec 2016 14:50

Publisher DOI:

10.1111/j.1365-3164.2007.00561.x

PubMed ID:

17222234

Web of Science ID:

000243309200003

URI:

https://boris.unibe.ch/id/eprint/23105 (FactScience: 39243)

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