Chlorhexidine and preservation of sound tooth structure in older adults. A placebo-controlled trial

Wyatt, Christopher C L; Maupome, Gerardo; Hujoel, Philippe P; MacEntee, Michael I; Persson, Gösta Rutger; Persson, Rigmor; Kiyak, H Asuman (2007). Chlorhexidine and preservation of sound tooth structure in older adults. A placebo-controlled trial. Caries research, 41(2), pp. 93-101. Basel: Karger 10.1159/000098041

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The Trial to Enhance Elderly Teeth Health (TEETH) was designed to test the impact of regular rinsing with a 0.12% chlorhexidine (CHX) solution on tooth loss, and the causes of tooth loss (caries, periodontal disease and trauma) were also investigated. This paper reports on the effectiveness of a 0.12% CHX solution for controlling caries using a tooth surface (coronal and root) survival analysis. A total of 1,101 low income elders in Seattle (United States) and Vancouver (Canada), aged 60-75 years, were recruited for a double-blind clinical trial and assigned to either a CHX (n = 550) or a placebo (n = 551) mouth rinse. Subjects alternated between daily rinsing for 1 month, followed by weekly rinsing for 5 months. All sound coronal and root surfaces at baseline were followed annually for up to 5 years. At each follow-up examination, those tooth surfaces with caries, restored, or extracted were scored as 'carious'. The hazard ratio associated with CHX for a sound surface to become filled, decayed, or extracted was 0.87 for coronal surfaces (95% confidence interval: 0.71-1.14, p = 0.20) and 0.91 for root surfaces (95% confidence interval: 0.73-1.14, p = 0.41). These findings suggest that regular rinsing with CHX does not have a substantial effect on the preservation of sound tooth structure in older adults.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Persson, Gösta Rutger and Persson, Rigmor


600 Technology > 610 Medicine & health






Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:54

Last Modified:

25 Jan 2017 12:17

Publisher DOI:


PubMed ID:


Web of Science ID:




URI: (FactScience: 40028)

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