Relation of white matter anisotropy to visual memory in 17 healthy subjects

Begré, Stefan; Frommer, Angela; von Känel, Roland; Kiefer, Claus; Federspiel, Andrea (2007). Relation of white matter anisotropy to visual memory in 17 healthy subjects. Brain research, 1168, pp. 60-66. Amsterdam: Elsevier 10.1016/j.brainres.2007.06.096

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We performed a Rey visual design learning test (RVDLT) in 17 subjects and measured intervoxel coherence (IC) by DTI as an indication of connectivity to investigate if visual memory performance would depend on white matter structure in healthy persons. IC considers the orientation of the adjacent voxels and has a better signal-to-noise ratio than the commonly used fractional anisotropy index. Voxel-based t-test analysis of the IC values was used to identify neighboring voxel clusters with significant differences between 7 low and 10 high test performers. We detected 9 circumscribed significant clusters (p< .01) with lower IC values in low performers than in high performers, with centers of gravity located in left and right superior temporal region, corpus callosum, left superior longitudinal fascicle, and left optic radiation. Using non-parametric correlation analysis, IC and memory performance were significantly correlated in each of the 9 clusters (r< .61 to r< .81; df=15, p< .01 to p< .0001). The findings provide in vivo evidence for the contribution of white matter structure to visual memory in healthy people.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued]
UniBE Contributor:	Begré, Stefan, von Känel, Roland, Federspiel, Andrea
ISSN:	0006-8993
ISBN:	17707351
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:55
Last Modified:	05 Dec 2022 14:17
Publisher DOI:	10.1016/j.brainres.2007.06.096
PubMed ID:	17707351
Web of Science ID:	000250041700007
URI:	https://boris.unibe.ch/id/eprint/23291 (FactScience: 41045)