Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

Chang, S Y; Yong, T F; Yu, C Y; Liang, M C; Pletnikova, O; Troncoso, J; Burgunder, J-M; Soong, T W (2007). Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand. Neuroscience, 145(3), pp. 1026-36. Oxford: Elsevier 10.1016/j.neuroscience.2006.12.054

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Ca(v)2.1 Ca(2+) channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca(2+)-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Burgunder, Jean-Marc

ISSN:

0306-4522

ISBN:

17291689

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1016/j.neuroscience.2006.12.054

PubMed ID:

17291689

Web of Science ID:

000245516000023

URI:

https://boris.unibe.ch/id/eprint/23303 (FactScience: 41107)

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