Kalus, P; Slotboom, J; Gallinat, J; Federspiel, A; Gralla, J; Remonda, L; Strik, WK; Schroth, G; Kiefer, C (2005). New evidence for involvement of the entorhinal region in schizophrenia: a combined MRI volumetric and DTI study. NeuroImage, 24(4), pp. 1122-9. San Diego, Calif.: Elsevier 10.1016/j.neuroimage.2004.10.007
Full text not available from this repository. (Request a copy)Postmortem examinations and magnetic resonance imaging (MRI) studies suggest involvement of the entorhinal cortex (EC) in schizophrenic psychoses. However, the extent and nature of the possible pathogenetical process underlying the observed alterations of this limbic key region for processing of multimodal sensory information remains unclear. Three-dimensional high-resolution MRI volumetry and evaluation of the regional diffusional anisotropy based on diffusion tensor imaging (DTI) were performed on the EC of 15 paranoid schizophrenic patients and 15 closely matched control subjects. In schizophrenic patients, EC volumes showed a slight, but not significant, decrease. However, the anisotropy values, expressed as inter-voxel coherences (COH), were found to be significantly decreased by 17.9% (right side) and 12.5% (left side), respectively, in schizophrenics. Reduction of entorhinal diffusional anisotropy can be hypothesized to be functionally related to disturbances in the perforant path, the principal efferent EC fiber tract supplying the limbic system with neuronal input from multimodal association centers. Combinations of different MRI modalities are a promising approach for the detection and characterization of subtle brain tissue alterations.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued] 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management |
UniBE Contributor: |
Federspiel, Andrea, Strik, Werner |
ISSN: |
1053-8119 |
ISBN: |
15670689 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1016/j.neuroimage.2004.10.007 |
PubMed ID: |
15670689 |
Web of Science ID: |
000226788100020 |
URI: |
https://boris.unibe.ch/id/eprint/23319 (FactScience: 41284) |
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