Assessment of bronchodilator responsiveness in preschool children using forced oscillations

Thamrin, Cindy; Gangell, Catherine L; Udomittipong, Kanokporn; Kusel, Merci M H; Patterson, Hilary; Fukushima, Takayoshi; Schultz, André; Hall, Graham L; Stick, Stephen M; Sly, Peter D (2007). Assessment of bronchodilator responsiveness in preschool children using forced oscillations. Thorax, 62(9), pp. 814-9. London: BMJ Publishing Group 10.1136/thx.2006.071290

Full text not available from this repository.

BACKGROUND: The forced oscillation technique (FOT) requires minimal patient cooperation and is feasible in preschool children. Few data exist on respiratory function changes measured using FOT following inhaled bronchodilators (BD) in healthy young children, limiting the clinical applications of BD testing in this age group. A study was undertaken to determine the most appropriate method of quantifying BD responses using FOT in healthy young children and those with common respiratory conditions including cystic fibrosis, neonatal chronic lung disease and asthma and/or current wheeze. METHODS: A pseudorandom FOT signal (4-48 Hz) was used to examine respiratory resistance and reactance at 6, 8 and 10 Hz; 3-5 acceptable measurements were made before and 15 min after the administration of salbutamol. The post-BD response was expressed in absolute and relative (percentage of baseline) terms. RESULTS: Significant BD responses were seen in all groups. Absolute changes in BD responses were related to baseline lung function within each group. Relative changes in BD responses were less dependent on baseline lung function and were independent of height in healthy children. Those with neonatal chronic lung disease showed a strong baseline dependence in their responses. The BD response in children with cystic fibrosis, asthma or wheeze (based on both group mean data and number of responders) was not greater than in healthy children. CONCLUSIONS: The BD response assessed by the FOT in preschool children should be expressed as a relative change to account for the effect of baseline lung function. The limits for a positive BD response of -40% and 65% for respiratory resistance and reactance, respectively, are recommended.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Thamrin, Cindy
ISSN:	0040-6376
ISBN:	17412777
Publisher:	BMJ Publishing Group
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 14:55
Last Modified:	05 Dec 2022 14:17
Publisher DOI:	10.1136/thx.2006.071290
PubMed ID:	17412777
Web of Science ID:	000249087500013
URI:	https://boris.unibe.ch/id/eprint/23372 (FactScience: 41644)