Nanoduct(R) sweat testing for rapid diagnosis in newborns, infants and children with cystic fibrosis

Desax, Marie-Claire; Ammann, Roland A; Hammer, Jürg; Schoeni, Martin H; Barben, Jürg (2008). Nanoduct(R) sweat testing for rapid diagnosis in newborns, infants and children with cystic fibrosis. European journal of pediatrics, 167(3), pp. 299-304. Berlin: Springer 10.1007/s00431-007-0485-0

Desax2008_Article_NanoductSweatTestingForRapidDi.pdf - Published Version
Available under License Publisher holds Copyright.

Download (220kB) | Preview

Determination of chloride concentration in sweat is the current diagnostic gold standard for Cystic Fibrosis (CF). Nanoduct(R) is a new analyzing system measuring conductivity which requires only 3 microliters of sweat and gives results within 30 minutes. The aim of the study was to evaluate the applicability of this system in a clinical setting of three children's hospitals and borderline results were compared with sweat chloride concentration. Over 3 years, 1,041 subjects were tested and in 946 diagnostic results were obtained. In 95 children, Nanoduct(R) failed (9.1% failure rate), mainly due to failures in preterm babies and newborns. Assuming 59 mmol/L as an upper limit of normal conductivity, all our 46 CF patients were correctly diagnosed (sensitivity 100%, 95% CI: 93.1-100; negative predicted value 100% (95% CI: 99.6-100) and only 39 non CF's were false positive (39/900, 4.3%; specificity 95.7%, 95%CI: 94.2-96.9, positive predicted value 54.1% with a 95%CI: 43.4-65.0). Increasing the diagnostic limit to 80 mmol/L, the rate fell to 0.3% (3/900). CF patients had a median conductivity of 115 mmol/L; the non-CF a median of 37 mmol/L. In conclusion, the Nanoduct(R) test is a reliable diagnostic tool for CF diagnosis: It has a failure rate comparable to other sweat tests and can be used as a simple bedside test for fast and reliable exclusion, diagnosis or suspicion of CF. In cases with borderline conductivity (60-80 mmol/L) other additional methods (determination of chloride and genotyping) are indicated.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Desax, Marie-Claire, Ammann, Roland, Schöni, Martin Heinrich










Anette van Dorland

Date Deposited:

04 Oct 2013 14:55

Last Modified:

05 Dec 2022 14:17

Publisher DOI:


PubMed ID:


Web of Science ID:




URI: (FactScience: 41674)

Actions (login required)

Edit item Edit item
Provide Feedback