Effects of antihypertensive drugs on blood pressure and proteinuria in childhood

Simonetti, Giacomo D; Rizzi, Mattia; Donadini, Rebecca; Bianchetti, Mario G (2007). Effects of antihypertensive drugs on blood pressure and proteinuria in childhood. Journal of hypertension, 25(12), pp. 2370-6. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/HJH.0b013e3282efeb7e

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BACKGROUND: Historically, there have been few drug trials for antihypertensive treatment in childhood and recommendations have been extrapolated from data obtained in adulthood. During the last decade an increased awareness of the risks of childhood hypertension stimulated clinical trials of antihypertensive agents in children. OBJECTIVE: The aim of this article is to systematically review the studies published between 1995 and 2006 that deal with the effect of antihypertensive drugs on childhood hypertension or proteinuria. METHODS: Medline, Current Contents, personal files and reference lists were used as data sources. RESULTS: Fifty-two out of 79 initially found reports were excluded. Consequently 27 articles were retained for the final analysis. The blood pressure reduction was similar with angiotensin-converting enzyme inhibitors (10.7/8.1 mmHg), angiotensin II receptor antagonists (10.5/6.9 mmHg) and calcium-channel blockers (9.3/7.2 mmHg). In addition angiotensin-converting enzyme inhibitors (by 49%) and angiotensin II receptor antagonists (by 59%) significantly reduced pathological proteinuria. CONCLUSIONS: The blood pressure reduction of angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and calcium-channel blockers is almost identical. In children with pathological proteinuria angiotensin-converting enzyme inhibitors or angiotensin II antagonists are superior to calcium-channel blockers.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Rizzi, Mattia and Bianchetti, Mario Giovanni

ISSN:

0263-6352

ISBN:

17984655

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1097/HJH.0b013e3282efeb7e

PubMed ID:

17984655

Web of Science ID:

000251165700002

URI:

https://boris.unibe.ch/id/eprint/23391 (FactScience: 41686)

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