Decreased EEG synchronization in Alzheimer's disease and mild cognitive impairment

Koenig, T.; Prichep, L.; Dierks, T.; Hubl, D.; Wahlund, L. O.; John, E. R.; Jelic, V. (2005). Decreased EEG synchronization in Alzheimer's disease and mild cognitive impairment. Neurobiology of aging, 26(2), pp. 165-171. New York, N.Y.: Elsevier 10.1016/j.neurobiolaging.2004.03.008

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The hypothesis of a functional disconnection of neuro-cognitive networks in patients with mild cognitive impairment (MCI) and Alzheimer Dementia was investigated using baseline resting EEG data. EEG databases from New York (264 subjects) and Stockholm (155 subjects), including healthy controls and patients with varying degrees of cognitive decline or Alzheimer Dementia were analyzed using Global Field Synchronization (GFS), a novel measure of global EEG synchronization. GFS reflects the global amount of phase-locked activity at a given frequency by a single number; it is independent of the recording reference and of implicit source models. Patients showed decreased GFS values in Alpha, Beta, and Gamma frequency bands, and increased GFS values in the Delta band, confirming the hypothesized disconnection syndrome. The results are discussed within the framework of current knowledge about the functional significance of the affected frequency bands.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse

UniBE Contributor:

König, Thomas; Dierks, Thomas and Hubl, Daniela

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0197-4580

ISBN:

15582746

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

10 Oct 2017 23:08

Publisher DOI:

10.1016/j.neurobiolaging.2004.03.008

PubMed ID:

15582746

Web of Science ID:

000226178800003

BORIS DOI:

10.7892/boris.23463

URI:

https://boris.unibe.ch/id/eprint/23463 (FactScience: 41906)

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