Anti-myelin antibodies in clinically isolated syndrome indicate the risk of multiple sclerosis in a Swiss cohort

Greeve, I; Sellner, J; Lauterburg, T; Walker, U; Rösler, KM; Mattle, HP; Swiss, Cohort (2007). Anti-myelin antibodies in clinically isolated syndrome indicate the risk of multiple sclerosis in a Swiss cohort. Acta neurologica Scandinavica, 116(4), pp. 207-10. Oxford: Blackwell Munksgaard 10.1111/j.1600-0404.2007.00872.x

Full text not available from this repository. (Request a copy)

OBJECTIVES: In patients with a clinically isolated syndrome (CIS), the time interval to convert to clinically definite multiple sclerosis (CDMS) is highly variable. Individual and geographical prognostic factors remain to be determined. Whether anti-myelin antibodies may predict the risk of conversion to CDMS in Swiss CIS patients of the canton Berne was the subject of the study. METHODS: Anti-myelin oligodendrocyte glycoprotein and anti-myelin basic protein antibodies were determined prospectively in patients admitted to our department. RESULTS: After a mean follow-up of 12 months, none of nine antibody-negative, but 22 of 30 antibody-positive patients had progressed to CDMS. Beta-Interferon treatment delayed the time to conversion from a mean of 7.4 to 10.9 months. CONCLUSIONS: In a Swiss cohort, antibody-negative CIS patients have a favorable short-term prognosis, and antibody-positive patients benefit from early treatment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Greeve, Isabell; Rösler, Kai Michael and Mattle, Heinrich

ISSN:

0001-6314

ISBN:

17824895

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1111/j.1600-0404.2007.00872.x

PubMed ID:

17824895

Web of Science ID:

000249220700002

URI:

https://boris.unibe.ch/id/eprint/23473 (FactScience: 41941)

Actions (login required)

Edit item Edit item
Provide Feedback