Cerebral disconnectivity: an early event in schizophrenia

Begré, S; Koenig, T (2008). Cerebral disconnectivity: an early event in schizophrenia. Neuroscientist, 14(1), pp. 19-45. Thousand Oaks, Calif.: Sage Publications 10.1177/1073858406298391

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Neuroimaging and electrophysiological investigations have demonstrated numerous differences in brain morphology and function of chronic schizophrenia patients compared to healthy controls. Studying patients at the beginning of their disease without the confounding effects of chronicity, medication, and institutionalization may provide a better understanding of schizophrenia. Recently, at many institutions around the world, special projects have been launched for specialized treatment and research of this interesting patient group. Using the PubMed search engine in this update, the authors summarize recent investigations between January 2002 and September 2006 that focus on whether signs of disconnectivity already exist early in the disease process. They discuss gray and white matter changes, their impact on symptomatology, electroencephalogram-based studies on connectivity, and possible influences of medication.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

Begré, Stefan and König, Thomas

ISSN:

1073-8584

ISBN:

17911212

Publisher:

Sage Publications

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

11 Dec 2014 22:00

Publisher DOI:

10.1177/1073858406298391

PubMed ID:

17911212

Web of Science ID:

000252403600012

BORIS DOI:

10.7892/boris.23480

URI:

https://boris.unibe.ch/id/eprint/23480 (FactScience: 41957)

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