MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury

Sturzenegger, M; Radanov, B P; Winter, P; Simko, M; Farra, A D; Di Stefano, G (2008). MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury. Acta neurologica Scandinavica, 117(1), pp. 49-54. Oxford: Blackwell Munksgaard 10.1111/j.1600-0404.2007.00939.x

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INTRODUCTION: Cognitive complaints, such as poor concentration and memory deficits, are frequent after whiplash injury and play an important role in disability. The origin of these complaints is discussed controversially. Some authors postulate brain lesions as a consequence of whiplash injuries. Potential diffuse axonal injury (DAI) with subsequent atrophy of the brain and ventricular expansion is of particular interest as focal brain lesions have not been documented so far in whiplash injury. OBJECTIVE: To investigate whether traumatic brain injury can be identified using a magnetic resonance (MR)-based quantitative analysis of normalized ventricle-brain ratios (VBR) in chronic whiplash patients with subjective cognitive impairment that cannot be objectively confirmed by neuropsychological testing. MATERIALS AND METHODS: MR examination was performed in 21 patients with whiplash injury and symptom persistence for 9 months on average and in 18 matched healthy controls. Conventional MR imaging (MRI) was used to assess the volumes of grey and white matter and of ventricles. The normalized VBR was calculated. RESULTS: The values of normalized VBR did not differ in whiplash patients when compared with that in healthy controls (F = 0.216, P = 0.645). CONCLUSIONS: This study does not support loss of brain tissue following whiplash injury as measured by VBR. On this basis, traumatic brain injury with subsequent DAI does not seem to be the underlying mechanism for persistent concentration and memory deficits that are subjectively reported but not objectively verifiable as neuropsychological deficits.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
UniBE Contributor:	Sturzenegger, Matthias
ISSN:	0001-6314
ISBN:	17949454
Publisher:	Blackwell Munksgaard
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:55
Last Modified:	05 Dec 2022 14:17
Publisher DOI:	10.1111/j.1600-0404.2007.00939.x
PubMed ID:	17949454
Web of Science ID:	000251584000007
URI:	https://boris.unibe.ch/id/eprint/23492 (FactScience: 42005)