Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress

Chlench, Sven; Mecha Disassa, Nigussie; Hohberg, Margret; Hoffmann, Christian; Pohlkamp, Theresa; Beyer, Gabriele; Bongrazio, Mauro; Da Silva-Azevedo, Luis; Baum, Oliver; Pries, Axel Radlach; Zakrzewicz, Andreas (2007). Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress. FEBS letters, 581(4), pp. 673-80. Amsterdam: Elsevier 10.1016/j.febslet.2007.01.028d

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Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6dyn/cm(2), 24h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

UniBE Contributor:

Baum, Oliver

ISSN:

0014-5793

ISBN:

17258205

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1016/j.febslet.2007.01.028d

PubMed ID:

17258205

Web of Science ID:

000244572300015

URI:

https://boris.unibe.ch/id/eprint/23525 (FactScience: 42204)

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