Walter, Marc; Wiesbeck, Gerhard A; Bloch, Nicole; Aeschbach, Sacha; Olbrich, Hans M; Seifritz, Erich; Dürsteler-MacFarland, Kenneth M (2008). Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients: A pilot study. European neuropsychopharmacology, 18(5), pp. 390-393. Amsterdam: Elsevier 10.1016/j.euroneuro.2008.01.005
Full text not available from this repository.Craving and stress frequently drive compulsive heroin use. Although methadone attenuates craving, drug-conditioned stimuli can trigger craving and possibly stress arousal in heroin-dependent patients receiving methadone maintenance. This study investigated drug cue-related craving, affectivity, and cortisol reactivity in 16 methadone-maintained patients before and after daily methadone. Unexpectedly, drug cues significantly increased craving after (t[15]=-4.27, p=0.001), but not before methadone intake. Patients displayed blunted cortisol response after post-methadone drug cues (t[15]=3.05, p=0.008) suggesting dissociated craving and cortisol reactivity after methadone intake of possible clinical relevance.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management |
UniBE Contributor: |
Seifritz, Erich |
ISSN: |
0924-977X |
ISBN: |
18299189 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1016/j.euroneuro.2008.01.005 |
PubMed ID: |
18299189 |
Web of Science ID: |
000255080600008 |
URI: |
https://boris.unibe.ch/id/eprint/23589 (FactScience: 42747) |
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