Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients: A pilot study

Walter, Marc; Wiesbeck, Gerhard A; Bloch, Nicole; Aeschbach, Sacha; Olbrich, Hans M; Seifritz, Erich; Dürsteler-MacFarland, Kenneth M (2008). Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients: A pilot study. European neuropsychopharmacology, 18(5), pp. 390-393. Amsterdam: Elsevier 10.1016/j.euroneuro.2008.01.005

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Craving and stress frequently drive compulsive heroin use. Although methadone attenuates craving, drug-conditioned stimuli can trigger craving and possibly stress arousal in heroin-dependent patients receiving methadone maintenance. This study investigated drug cue-related craving, affectivity, and cortisol reactivity in 16 methadone-maintained patients before and after daily methadone. Unexpectedly, drug cues significantly increased craving after (t[15]=-4.27, p=0.001), but not before methadone intake. Patients displayed blunted cortisol response after post-methadone drug cues (t[15]=3.05, p=0.008) suggesting dissociated craving and cortisol reactivity after methadone intake of possible clinical relevance.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Seifritz, Erich

ISSN:

0924-977X

ISBN:

18299189

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

17 Mar 2015 22:02

Publisher DOI:

10.1016/j.euroneuro.2008.01.005

PubMed ID:

18299189

Web of Science ID:

000255080600008

URI:

https://boris.unibe.ch/id/eprint/23589 (FactScience: 42747)

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