Decision-making dysregulation in first-episode schizophrenia

Cattapan-Ludewig, Katja; Ludewig, Stephan; Messerli, Nadine; Vollenweider, Franz X; Seitz, Antonia; Feldon, Joram; Paulus, Martin P (2008). Decision-making dysregulation in first-episode schizophrenia. Journal of nervous and mental disease, 196(2), pp. 157-60. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/NMD.0b013e318162aa1b

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Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management 07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
UniBE Contributor:	Cattapan-Ludewig, Katja, Messerli, Nadine, Seitz, Andrea
ISSN:	0022-3018
ISBN:	18277225
Publisher:	Lippincott Williams & Wilkins
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:55
Last Modified:	05 Dec 2022 14:17
Publisher DOI:	10.1097/NMD.0b013e318162aa1b
PubMed ID:	18277225
Web of Science ID:	000253272500011
URI:	https://boris.unibe.ch/id/eprint/23593 (FactScience: 42762)