Decision-making dysregulation in first-episode schizophrenia

Cattapan-Ludewig, Katja; Ludewig, Stephan; Messerli, Nadine; Vollenweider, Franz X; Seitz, Antonia; Feldon, Joram; Paulus, Martin P (2008). Decision-making dysregulation in first-episode schizophrenia. Journal of nervous and mental disease, 196(2), pp. 157-60. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/NMD.0b013e318162aa1b

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Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Cattapan-Ludewig, Katja; Messerli, Nadine and Seitz, Andrea






Lippincott Williams & Wilkins




Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

17 Mar 2015 22:02

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Web of Science ID:


URI: (FactScience: 42762)

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