Engelhardt, Brian G; Holland, Derek W; Brandt, Stephen J; Chinratanalab, Wichai; Goodman, Stacey A; Greer, John P; Jagasia, Madan H; Kassim, Adetola A; Morgan, David S; Ruffner, Katherine L; Schuening, Friedrich G; Wolff, Steven; Bitting, Rhonda; Sulur, Paulgun; Stein, Richard S (2007). High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leukemia & lymphoma, 48(9), pp. 1728-35. London: Informa Healthcare 10.1080/10428190701534374
Full text not available from this repository.Between January 1990 and April 2001, 115 patients received high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) for relapsed or refractory Hodgkin lymphoma (HL). With a median follow-up of 58 months (range, 1 - 175 months), 5-year progression-free survival (PFS) and overall survival (OS) were 46% and 58%, respectively. Twelve patients with primary refractory disease had a 5-year PFS of 41% and OS of 58%, not significantly different from those of the remaining cohort. Early and overall regimen related mortality were 7% and 16%, respectively. Male gender (P = 0.04) and a time to relapse (TTR) < 12 months (P = 0.03) were associated with decreased OS by univariate analysis. In multivariate analysis, TTR < 12 months remained statistically significant (P = 0.04). We have confirmed that HDT and ASCT result in long-term survival for a proportion of patients with relapsed or refractory HL. All patients, including those with primary refractory disease, benefited from HDT and ASCT.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Engelhardt, Britta |
ISSN: |
1042-8194 |
ISBN: |
17786708 |
Publisher: |
Informa Healthcare |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1080/10428190701534374 |
PubMed ID: |
17786708 |
Web of Science ID: |
000249764200011 |
URI: |
https://boris.unibe.ch/id/eprint/23653 (FactScience: 43299) |
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