High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes

Engelhardt, Brian G; Holland, Derek W; Brandt, Stephen J; Chinratanalab, Wichai; Goodman, Stacey A; Greer, John P; Jagasia, Madan H; Kassim, Adetola A; Morgan, David S; Ruffner, Katherine L; Schuening, Friedrich G; Wolff, Steven; Bitting, Rhonda; Sulur, Paulgun; Stein, Richard S (2007). High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leukemia & lymphoma, 48(9), pp. 1728-35. London: Informa Healthcare 10.1080/10428190701534374

Full text not available from this repository. (Request a copy)

Between January 1990 and April 2001, 115 patients received high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) for relapsed or refractory Hodgkin lymphoma (HL). With a median follow-up of 58 months (range, 1 - 175 months), 5-year progression-free survival (PFS) and overall survival (OS) were 46% and 58%, respectively. Twelve patients with primary refractory disease had a 5-year PFS of 41% and OS of 58%, not significantly different from those of the remaining cohort. Early and overall regimen related mortality were 7% and 16%, respectively. Male gender (P = 0.04) and a time to relapse (TTR) < 12 months (P = 0.03) were associated with decreased OS by univariate analysis. In multivariate analysis, TTR < 12 months remained statistically significant (P = 0.04). We have confirmed that HDT and ASCT result in long-term survival for a proportion of patients with relapsed or refractory HL. All patients, including those with primary refractory disease, benefited from HDT and ASCT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

1042-8194

ISBN:

17786708

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1080/10428190701534374

PubMed ID:

17786708

Web of Science ID:

000249764200011

URI:

https://boris.unibe.ch/id/eprint/23653 (FactScience: 43299)

Actions (login required)

Edit item Edit item
Provide Feedback