Platelet GPIb complex as a target for anti-thrombotic drug development

Clemetson, Kenneth J; Clemetson, Jeannine M (2008). Platelet GPIb complex as a target for anti-thrombotic drug development. Thrombosis and haemostasis, 99(3), pp. 473-9. Stuttgart: Schattauer 10.1160/TH07-12-0718

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Specific inhibition of platelet function is a major target of anti-thrombotic drug research. Platelet receptors are both accessible and specific but have multiple functions often linked to a wide range of ligands. GPIb complex is best known as a major platelet receptor for von Willebrand factor essential for platelet adhesion under high shear conditions found in arteries and in thrombosis. Recent animal studies have supported inhibition of GPIb as a good candidate for anti-thrombotic drug development with several classes of proteins showing important specific effects and the required discrimination between roles in haemostasis and thrombosis is important to protect against bleeding complications. These include antibodies, several classes of snake venom proteins, mutant thrombin molecules and peptides affecting subunit interactions. However, due to the nature of its receptor-ligand interactions involving large protein-protein interfaces, the possibility of developing classic pharmaceutical inhibitors for long term (and perhaps oral) treatment is still unclear, and additional information about structural interactions and signalling mechanisms is essential.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Clemetson, Kenneth John and Clemetson, Jeannine

ISSN:

0340-6245

ISBN:

18327394

Publisher:

Schattauer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1160/TH07-12-0718

PubMed ID:

18327394

Web of Science ID:

000254171300006

URI:

https://boris.unibe.ch/id/eprint/23657 (FactScience: 43318)

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