L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells

Guarda, Greta; Hons, Miroslav; Soriano, Silvia F; Huang, Alex Y; Polley, Rosalind; Martín-Fontecha, Alfonso; Stein, Jens V; Germain, Ronald N; Lanzavecchia, Antonio; Sallusto, Federica (2007). L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nature immunology, 8(7), pp. 743-52. New York, N.Y.: Nature Publishing Group 10.1038/ni1469

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T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7- effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Hons, Miroslav and Stein, Jens Volker

ISSN:

1529-2908

ISBN:

17529983

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1038/ni1469

PubMed ID:

17529983

Web of Science ID:

000247718100015

URI:

https://boris.unibe.ch/id/eprint/23661 (FactScience: 43328)

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