Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway

Meli, Damian N.; Christen, Stephan; Leib, Stephen L. (2003). Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. Journal of infectious diseases, 187(9), pp. 1411-1415. Cary, N.C.: The University of Chicago Press 10.1086/374644

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In experimental bacterial meningitis, matrix metalloproteinases (MMPs) and reactive oxygen species (ROS) contribute to brain damage. MMP-9 increases in cerebrospinal fluid (CSF) during bacterial meningitis and is associated with the brain damage that is a consequence of the disease. This study assesses the origin of MMP-9 in bacterial meningitis and how ROS modulate its activity. Rat brain-slice cultures and rat polymorphonuclear cells (PMNs) that had been challenged with capsule-deficient heat-inactivated Streptococcus pneumoniae R6 (hiR6) released MMP-9. Coincubation with either catalase, with the myeloperoxidase inhibitor azide, or with the hypochlorous acid scavenger methionine almost completely prevented activation, but not the release, of MMP-9, in supernatants of human PMNs stimulated with hiR6. Thus, in bacterial meningitis, both brain-resident cells and invading PMNs may act as sources of MMP-9, and stimulated PMNs may activate MMP-9 via an ROS-dependent pathway. MMP-9 activation by ROS may represent a target for therapeutic intervention in bacterial meningitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Christen, Stephan and Leib, Stephen

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0022-1899

ISBN:

12717622

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

31 Oct 2019 04:03

Publisher DOI:

10.1086/374644

PubMed ID:

12717622

Web of Science ID:

000182273700008

BORIS DOI:

10.7892/boris.23685

URI:

https://boris.unibe.ch/id/eprint/23685 (FactScience: 43474)

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