Wegener's granulomatosis presenting as pyoderma gangrenosum

Boudny, Clara; Nievergelt, Helga; Braathen, Lasse R; Simon, Dagmar (2007). Wegener's granulomatosis presenting as pyoderma gangrenosum. Journal der Deutschen Dermatologischen Gesellschaft, 6(6), pp. 477-479. Berlin: Blackwell 10.1111/j.1610-0387.2007.06497.x

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Half of the patients with Wegener's granulomatosis develop skin lesions due to the systemic vasculitis. Wegener's granulomatosis should be included in the differential diagnostic considerations for necrotic ulcers, including leg ulcers. We present a case which demonstrates the importance of histological evaluation of a skin biopsy from the margin of the ulcer for establishing the diagnosis. Antineutrophil cytoplasmic antibodies with antigen specificity for proteinase 3 (PR3-ANCA) were detected supporting the diagnosis of Wegener granulomatosis. Further evaluation showed involvement of the eyes and kidneys. The ulcer rapidly healed under treatment with cyclophosphamide and corticosteroids.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Nievergelt, Helga; Braathen, Lasse Roger and Simon, Dagmar

ISSN:

1610-0379

ISBN:

18076660

Publisher:

Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

08 Jun 2016 10:43

Publisher DOI:

10.1111/j.1610-0387.2007.06497.x

PubMed ID:

18076660

Web of Science ID:

000256802100007

URI:

https://boris.unibe.ch/id/eprint/23726 (FactScience: 43788)

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