Multimodal imaging in macular diagnostics: combined OCT-SLO improves therapeutical monitoring

Brinkmann, Christian Karl; Wolf, Sebastian; Wolf-Schnurrbusch, Ute Ellen Kathrin (2008). Multimodal imaging in macular diagnostics: combined OCT-SLO improves therapeutical monitoring. Graefe's archive for clinical and experimental ophthalmology, 246(1), pp. 9-16. Berlin: Springer-Verlag 10.1007/s00417-007-0655-9

[img]
Preview
Text
417_2007_Article_655.pdf - Published Version
Available under License Publisher holds Copyright.

Download (845kB) | Preview

BACKGROUND: Digital imaging methods are a centrepiece for diagnosis and management of macular disease. A recently developed imaging device is composed of simultaneous confocal scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT). By means of clinical samples the benefit of this technique concerning diagnostic and therapeutic follow-up will be assessed. METHODS: The combined OCT-SLO-System (Ophthalmic Technologies Inc., Toronto, Canada) allows for confocal en-face fundus imaging and high resolution OCT scanning at the same time. OCT images are obtained from transversal line scans. One light source and the identical scanning rate yield a pixel-to-pixel correspondence of images. Three-dimensional thickness maps are derived from C-scan stacking. RESULTS: We followed-up patients with cystoid macular edema, pigment epithelium detachment, macular hole, venous branch occlusion, and vitreoretinal tractions during their course of therapy. The new imaging method illustrates the reduction of cystoid volume, e.g. after intravitreal injections of either angiostatic drugs or steroids. C-scans are used for appreciation of lesion diameters, visualisation of pathologies involving the vitreoretinal interface, and quantification of retinal thickness change. CONCLUSION: The combined OCT-SLO system creates both topographic and tomographic images of the retina. New therapeutic options can be followed-up closely by observing changes in lesion thickness and cyst volumes. For clinical use further studies are needed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Brinkmann, Christian Karl; Wolf, Sebastian and Wolf-Schnurrbusch, Ute

ISSN:

0721-832X

ISBN:

17674015

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

26 Jun 2018 13:51

Publisher DOI:

10.1007/s00417-007-0655-9

PubMed ID:

17674015

Web of Science ID:

000251092800002

BORIS DOI:

10.7892/boris.23773

URI:

https://boris.unibe.ch/id/eprint/23773 (FactScience: 44380)

Actions (login required)

Edit item Edit item
Provide Feedback