Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy

Rizzo, Manfredi; Trepp, Roman; Berneis, Kaspar; Christ, Emanuel R (2007). Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy. European journal of endocrinology, 156(3), pp. 361-7. Bristol: BioScientifica Ltd. 10.1530/EJE-06-0652

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Patients with growth hormone deficiency (GHD) have increased cardiovascular risk and may show elevated triglyceride and reduced high density lipoprotein (HDL) cholesterol concentrations, two lipid abnormalities usually accompanied by increased small dense LDL in the 'atherogenic lipoprotein phenotype' (ALP). In the present study, we directly investigated (1) whether hypopituitary patients with GHD have increased small dense LDL; (2) whether growth hormone replacement therapy (GHRT) beneficially impact on such particles; (3) the prevalence of ALP in GHD and GHRT patients.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
UniBE Contributor:	Trepp, Roman, Christ, Emanuel
ISSN:	0804-4643
ISBN:	17322496
Publisher:	BioScientifica Ltd.
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.1530/EJE-06-0652
PubMed ID:	17322496
Web of Science ID:	000245358300011
URI:	https://boris.unibe.ch/id/eprint/23779 (FactScience: 44396)