[Endogenous hypercortisolism and immunologically-mediated disease: three cases]

Sahli, R; Diem, P; Christ, ER (2005). [Endogenous hypercortisolism and immunologically-mediated disease: three cases]. Deutsche medizinische Wochenschrift, 130(41), pp. 2316-8. Stuttgart: Thieme 10.1055/s-2005-918569

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We report three women with hypercortisolism presenting with symptoms and signs of Cushing's syndrome. In two of the patients, initial symptoms of hypercortisolism were associated with spontaneous amelioration of previously known atopic dermatitis and psoriasis, respectively. DIAGNOSTIC PROCEDURES: Diagnosis was established by demonstrating both lack of responsiveness to dexamethasone (1mg) suppression test and increased 24-hour urine cortisol secretion. One patient had a low serum ACTH level indicating Cushing's syndrome of adrenal origin. In the other two patients hypercortisolism proved to be ACTH-dependent, the source being the pituitary, as demonstrated by CRH stimulation test (elevation of ACTH and cortisol by 35 % and 20 %, respectively) and sampling of the petrosus sinus. In both patients imaging confirmed the presence of a pituitary adenoma.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Sahli, Rahel Gerda; Diem, Peter and Christ, Emanuel

ISSN:

0012-0472

ISBN:

16231230

Publisher:

Thieme

Language:

German

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

06 Dec 2013 13:47

Publisher DOI:

10.1055/s-2005-918569

PubMed ID:

16231230

Web of Science ID:

000232579200002

URI:

https://boris.unibe.ch/id/eprint/23848 (FactScience: 44833)

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