Glucose homeostasis and insulin secretion in human recipients of pancreas transplantation

Robertson, RP; Abid, M; Sutherland, D.E.; Diem, P (1989). Glucose homeostasis and insulin secretion in human recipients of pancreas transplantation. Diabetes, 1(38), pp. 97-8. Alexandria, Va.: American Diabetes Association

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To ascertain the consequences of pancreas transplantation with systemic venous drainage on glucose homeostasis and insulin secretion, glucose and insulin responses to intravenous glucose were compared in 10 recipients and 15 normal control subjects. There were no differences in fasting glucose levels or intravenous glucose disappearance rates. However, basal insulin levels and acute insulin responses to glucose were threefold greater in the recipients. It is not clear whether this consequence of hyperinsulinemia in the recipients is due to the abnormal circulatory drainage, the lack of autonomic input, or concurrent immunosuppressive drug therapy.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
UniBE Contributor:	Diem, Peter
ISSN:	0012-1797
ISBN:	2642865
Publisher:	American Diabetes Association
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	05 Dec 2022 14:17
PubMed ID:	2642865
Web of Science ID:	A1989R717700029
URI:	https://boris.unibe.ch/id/eprint/23889 (FactScience: 44924)