Glucose homeostasis and insulin secretion in human recipients of pancreas transplantation

Robertson, RP; Abid, M; Sutherland, D.E.; Diem, P (1989). Glucose homeostasis and insulin secretion in human recipients of pancreas transplantation. Diabetes, 1(38), pp. 97-8. Alexandria, Va.: American Diabetes Association

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To ascertain the consequences of pancreas transplantation with systemic venous drainage on glucose homeostasis and insulin secretion, glucose and insulin responses to intravenous glucose were compared in 10 recipients and 15 normal control subjects. There were no differences in fasting glucose levels or intravenous glucose disappearance rates. However, basal insulin levels and acute insulin responses to glucose were threefold greater in the recipients. It is not clear whether this consequence of hyperinsulinemia in the recipients is due to the abnormal circulatory drainage, the lack of autonomic input, or concurrent immunosuppressive drug therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Diem, Peter

ISSN:

0012-1797

ISBN:

2642865

Publisher:

American Diabetes Association

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

04 May 2014 23:16

PubMed ID:

2642865

Web of Science ID:

A1989R717700029

URI:

https://boris.unibe.ch/id/eprint/23889 (FactScience: 44924)

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