Lymphocyte transformation by insulin and insulin-zinc suspensions

Diem, P; Spengler, H; de Weck, AL (1982). Lymphocyte transformation by insulin and insulin-zinc suspensions. Clinical and experimental immunology, 50(1), pp. 155-62. Oxford: Blackwell Scientific Publications

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The lymphocyte transformation response to the mitogen phytohaemagglutinin (PHA) was determined in 15 well controlled insulin-dependent diabetics (IDD) with a history of insulin allergy or an acute insulin allergy. There was no significant difference in the PHA response of IDD and normal subjects matched in respect of age and sex. The response of peripheral blood lymphocytes to insulin (Actrapid) and an insulin zinc suspension (Monotard) was also determined. Fifty-three percent of IDD gave a positive reaction to Actrapid. Monotard produced positive reactions both in IDD and normal subjects. In normal subjects, a close correlation between the stimulation indices of Monotard and PHA was found (r = 0 . 966) suggesting that these stimulations depend on a common parameter namely, the reactivity to mitogens.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
UniBE Contributor:	Diem, Peter
ISSN:	0009-9104
ISBN:	6756727
Publisher:	Blackwell Scientific Publications
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	05 Dec 2022 14:17
PubMed ID:	6756727
Web of Science ID:	A1982PJ28800021
URI:	https://boris.unibe.ch/id/eprint/23891 (FactScience: 44930)