Capsule genes of Streptococcus pneumoniae influence growth in vitro

Bättig, Patrick; Mühlemann, Kathrin (2007). Capsule genes of Streptococcus pneumoniae influence growth in vitro. FEMS immunology and medical microbiology, 50(3), pp. 324-9. Oxford: Blackwell 10.1111/j.1574-695X.2007.00246.x

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Recently, we showed that the in vitro lag phase correlates with the pneumococcal serotype. This study investigated the role of capsule genes in bacterial growth using strain D39. Deletion of the entire capsule operon induced a significantly prolonged lag phase in Todd Hewitt broth (P=0.0002). However, partial deletions showed a different influence on the lag phase. Supplementation of media with 5% fetal bovine serum restored normal growth, at least partially, in mutants with a prolonged lag phase. Therefore, pneumococcal capsule gene products influence bacterial growth in vitro in strain D39.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Mühlemann, Kathrin

ISSN:

0928-8244

ISBN:

17578523

Publisher:

Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1111/j.1574-695X.2007.00246.x

PubMed ID:

17578523

Web of Science ID:

000247817800006

URI:

https://boris.unibe.ch/id/eprint/23939 (FactScience: 45285)

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