Current state of the art in myocardial tissue engineering

Giraud, Marie-Noëlle; Armbruster, Christine; Carrel, Thierry; Tevaearai, Hendrik T (2007). Current state of the art in myocardial tissue engineering. Tissue engineering, 13(8), pp. 1825-36. Larchmont, N.Y.: Mary Ann Liebert 10.1089/ten.2006.0110

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Myocardial tissue engineering aims to repair, replace, and regenerate damaged cardiac tissue using tissue constructs created ex vivo. This approach may one day provide a full treatment for several cardiac disorders, including congenital diseases or ventricular dysfunction after myocardial infarction. Although the ex vivo construction of a myocardium-like tissue is faced with many challenges, it is nevertheless a pressing objective for cardiac reparative medicine. Multidisciplinary efforts have already led to the development of promising viable muscle constructs. In this article, we review the various concepts of cardiac tissue engineering and their specific challenges. We also review the different types of existing biografts and their physiological relevance. Although many investigators have favored cardiomyocytes, we discuss the potential of other clinically relevant cells, as well as the various hypotheses proposed to explain the functional benefit of cell transplantation.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery
UniBE Contributor:	Giraud, Marie-Noelle, Armbruster, Christine, Carrel, Thierry, Tevaearai, Hendrik
ISSN:	1076-3279
ISBN:	17518754
Publisher:	Mary Ann Liebert
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	27 Feb 2024 14:29
Publisher DOI:	10.1089/ten.2006.0110
PubMed ID:	17518754
Web of Science ID:	000248742200004
URI:	https://boris.unibe.ch/id/eprint/23956 (FactScience: 45418)