Current state of the art in myocardial tissue engineering

Giraud, Marie-Noëlle; Armbruster, Christine; Carrel, Thierry; Tevaearai, Hendrik T (2007). Current state of the art in myocardial tissue engineering. Tissue engineering, 13(8), pp. 1825-36. Larchmont, N.Y.: Mary Ann Liebert 10.1089/ten.2006.0110

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Myocardial tissue engineering aims to repair, replace, and regenerate damaged cardiac tissue using tissue constructs created ex vivo. This approach may one day provide a full treatment for several cardiac disorders, including congenital diseases or ventricular dysfunction after myocardial infarction. Although the ex vivo construction of a myocardium-like tissue is faced with many challenges, it is nevertheless a pressing objective for cardiac reparative medicine. Multidisciplinary efforts have already led to the development of promising viable muscle constructs. In this article, we review the various concepts of cardiac tissue engineering and their specific challenges. We also review the different types of existing biografts and their physiological relevance. Although many investigators have favored cardiomyocytes, we discuss the potential of other clinically relevant cells, as well as the various hypotheses proposed to explain the functional benefit of cell transplantation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Giraud, Marie-Noelle; Armbruster, Christine; Carrel, Thierry and Tevaearai, Hendrik

ISSN:

1076-3279

ISBN:

17518754

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1089/ten.2006.0110

PubMed ID:

17518754

Web of Science ID:

000248742200004

URI:

https://boris.unibe.ch/id/eprint/23956 (FactScience: 45418)

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