Minimal extracorporeal circulation is a promising technique for coronary artery bypass grafting

Immer, Franz F; Ackermann, Andreas; Gygax, Erich; Stalder, Mario; Englberger, Lars; Eckstein, Friedrich S; Tevaearai, Hendrik T; Schmidli, Juerg; Carrel, Thierry P (2007). Minimal extracorporeal circulation is a promising technique for coronary artery bypass grafting. Annals of thoracic surgery, 84(5), 1515-20; discussion 1521. New York, N.Y.: Elsevier 10.1016/j.athoracsur.2007.05.069

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BACKGROUND: Minimal extracorporeal circulation (MECC) is a promising perfusion technology, taking the advantage of an ECC while having a significantly reduced priming volume. We analyzed the actual possible benefits of using MECC in patients undergoing CABG procedures and compared the results with conventional extracorporeal circulation (CECC). METHODS: One thousand fifty-three consecutive patients underwent CABG surgery using the MECC perfusion technique. Subgroup analyses focused on perioperative myocardial markers (cardiac troponin I [cTnI]), incidence of atrial fibrillation (AF), and perioperative evaluation of inflammatory markers and data were compared with those of patients who underwent CABG using CECC. A propensity score analysis was performed. RESULTS: Patient characteristics and distribution of EuroSCORE risk were similar in both groups. Severity of coronary artery disease and extent of revascularization were also comparable in both groups (number of distal anastomoses: 3.2 +/- 1.1 in CECC vs 3.2 +/- 0.9 in MECC; p = not significant [ns]). The cTnI was significantly lower in the MECC group (11.0 +/- 10.8 microg/L in MECC vs 24.7 +/- 25.3 microg/L in CECC; p < 0.05). Incidence of AF was 11.1% in MECC and 39.0% in CECC (p < 0.05). Inflammatory markers (interleukin-6, SC5b-9) were lower in MECC patients (p < 0.05). Propensity score analysis confirmed faster recovery in MECC patients and lower incidence of AF. CONCLUSIONS: Minimal extracorporeal circulation is a safe perfusion technique for CABG and may therefore concurrence OPCAB and traditional CABG under CECC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Immer, Franz F.; Stalder, Mario; Englberger, Lars; Eckstein, Friedrich Stefan; Tevaearai, Hendrik; Schmidli, Jürg and Carrel, Thierry

ISSN:

0003-4975

ISBN:

17954055

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1016/j.athoracsur.2007.05.069

PubMed ID:

17954055

Web of Science ID:

000250782500013

URI:

https://boris.unibe.ch/id/eprint/23963 (FactScience: 45437)

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