Two-year clinical outcome after implantation of sirolimus-eluting and paclitaxel-eluting stents in diabetic patients

Billinger, Michael; Beutler, Jonas; Taghetchian, Keywan R; Remondino, Andrea; Wenaweser, Peter; Cook, Stéphane; Togni, Mario; Seiler, Christian; Stettler, Christoph; Eberli, Franz R; Lüscher, Thomas F; Wandel, Simon; Jüni, Peter; Meier, Bernhard; Windecker, Stephan (2008). Two-year clinical outcome after implantation of sirolimus-eluting and paclitaxel-eluting stents in diabetic patients. European Heart Journal, 29(6), pp. 718-25. Oxford: Oxford University Press 10.1093/eurheartj/ehn021

ehn021.pdf - Published Version
Available under License Publisher holds Copyright.

Download (311kB) | Preview

Aims Percutaneous coronary intervention (PCI) in diabetic patients is associated with an increased risk of restenosis and major adverse cardiac events (MACE). We assessed the impact of diabetes on long-term outcome after PCI with sirolimus-eluting (SES) and paclitaxel-eluting (PES) stents. Methods and results In the SIRTAX trial, 1012 patients were randomized to treatment with SES (n = 503) or PES (n = 509). A stratified analysis of outcomes was performed according to the presence or absence of diabetes. Baseline characteristics were well balanced between SES and PES in patients with (N = 201) and without diabetes (N = 811). Clinical outcome was worse in diabetic compared with non-diabetic patients regarding death (9.0% vs. 4.1%, P = 0.004) and MACE (defined as cardiac death, myocardial infarction, or TLR; 19.9% vs. 12.7%, P = 0.007) at 2 years. Among diabetic patients, SES reduced MACE by 47% (14.8% vs. 25.8%, HR = 0.52, P = 0.05) and TLR by 61% (7.4% vs. 17.2%, HR = 0.39, P = 0.03) compared with PES at 2 years. Conclusion Diabetic patients have worse prognosis than non-diabetic patients undergoing PCI with DES. Among the diabetic patient population of this trial, SES reduce repeat revascularization procedures and MACE more effectively than PES and to a similar degree as in non-diabetic patients.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Billinger, Michael, Wenaweser, Peter Martin, Cook, Stéphane, Togni, Mario, Seiler, Christian, Stettler, Christoph, Eberli, Franz, Wandel, Simon, Jüni, Peter, Meier, Bernhard, Windecker, Stephan






Oxford University Press




Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

05 Dec 2022 14:17

Publisher DOI:


PubMed ID:


Web of Science ID:




URI: (FactScience: 45539)

Actions (login required)

Edit item Edit item
Provide Feedback