Hemoglobin Vesicles to Treat Critical Ischemia

Erni, Dominique; Wettstein, Reto; Contaldo, Claudio; Plock, Jan A.; Rafatmehr, Nassim; Sakai, Hiromi; Tsuchida, Eishun (2007). Hemoglobin Vesicles to Treat Critical Ischemia. Artificial blood, 15(2), pp. 58-64. The Society of Blood Substitutes, Japan

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The initital purpose for developing artificial oxygen carriers was to replace blood transfusions in order to avoid their adverse effects such as immunologic reactions, transmission of infectious diseases, limited availability and restricted storage conditions. With the advent of new generations of artifical oxygen carriers, a shift of paradigm evolved that considers the artificial oxygen carriers as oxygen therapeutics re-distributing oxygen delivery in the favor of tissues in need. This function may find a particular application in tissues rendered hypoxic due to arterial occlusive diseases. This review, based on a large series of intravital microscopy studies in a hamster skin flap model, outlines the optimal design of hemoglobin vesicles?HbVs?given for the above intention. In summary, the HbV should be of a large diameter, and oxygen affinity, colloid osmotic pressure and viscosity of the HbV solution should be high.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery

UniBE Contributor:

Erni, Dominique; Plock, Jan Alexander and Rafatmehr, Nassim

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1341-1594

Publisher:

The Society of Blood Substitutes, Japan

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:56

Last Modified:

12 Jan 2015 13:27

BORIS DOI:

10.7892/boris.23993

URI:

https://boris.unibe.ch/id/eprint/23993 (FactScience: 45691)

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