Relation of depression to various markers of coagulation and fibrinolysis in patients with and without coronary artery disease

Schroeder, Verena; Borner, Urs; Gutknecht, Stefan; Schmid, Jean-Paul; Saner, Hugo; Kohler, Hans P (2007). Relation of depression to various markers of coagulation and fibrinolysis in patients with and without coronary artery disease. European journal of cardiovascular prevention & rehabilitation, 14(6), pp. 782-787. Los Angeles, Calif.: Sage 10.1097/HJR.0b013e32828622e8

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BACKGROUND: It has been suggested that changes in blood coagulation and fibrinolysis might explain the observed association between depression and coronary artery disease (CAD). So far, only a few coagulation factors have been investigated in this regard, and the results were not consistent. DESIGN: The aim of our study was to analyse a broad range of coagulation and fibrinolytic factors, with emphasis on factors directly involved in clot formation and degradation or reflecting coagulation activation, in patients with CAD and controls without CAD, as assessed by coronary angiography, who also underwent a diagnostic procedure for depression. METHODS: We screened 306 patients with CAD and controls without CAD for depression using the Hospital Anxiety and Depression Scale and Allgemeine Depressions Skala-L questionnaires. In participants with positive screening result, diagnosis of major depression was confirmed or excluded by a structured interview. We analysed the following coagulation and fibrinolytic factors: fibrinogen, prothrombin fragment F1+2, factor XIII A-subunit, factor XIII B-subunit, tissue plasminogen activator, plasminogen activator inhibitor-1, thrombin-activable fibrinolysis inhibitor, and D-dimer. RESULTS: We did not observe significant associations between depression and CAD, nor between depression and cardiovascular risk factors. Coagulation and fibrinolytic factors showed no differences between patients with CAD and controls, but they were associated with several cardiovascular risk factors. Depression was not associated with coagulation and fibrinolytic factors. No associations were found either when both CAD and depression were taken into account. CONCLUSION: Our study gives no evidence that there is a significant relation among depression, CAD, and blood coagulation and fibrinolysis.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Thromboselabor Kinderklinik [discontinued] 04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Schröder, Verena, Schmid-Walker, Jean-Paul, Saner, Hugo Ernst, Kohler, Hans-Peter
ISSN:	1741-8267
ISBN:	18043299
Publisher:	Sage
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.1097/HJR.0b013e32828622e8
PubMed ID:	18043299
Web of Science ID:	000252230100010
URI:	https://boris.unibe.ch/id/eprint/24061 (FactScience: 46613)