Indocyanine green plasma disappearance rate during the anhepatic phase of orthotopic liver transplantation

Bruegger, Lukas; Studer, Peter; Schmid, Stefan W; Pestel, Gunther; Reichen, Juerg; Seiler, Christian; Candinas, Daniel; Inderbitzin, Daniel (2008). Indocyanine green plasma disappearance rate during the anhepatic phase of orthotopic liver transplantation. Journal of gastrointestinal surgery, 12(1), pp. 67-72. New York, N.Y.: Springer-Verlag 10.1007/s11605-007-0352-3

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Non-invasive pulse spectrophotometry to measure indocyanine green (ICG) elimination correlates well with the conventional invasive ICG clearance test. Nevertheless, the precision of this method remains unclear for any application, including small-for-size liver remnants. We therefore measured ICG plasma disappearance rate (PDR) during the anhepatic phase of orthotopic liver transplantation using pulse spectrophotometry. Measurements were done in 24 patients. The median PDR after exclusion of two outliers and two patients with inconstant signal was 1.55%/min (95% confidence interval [CI]=0.8-2.2). No correlation with patient age, gender, body mass, blood loss, administration of fresh frozen plasma, norepinephrine dose, postoperative albumin (serum), or difference in pre and post transplant body weight was detected. In conclusion, we found an ICG-PDR different from zero in the anhepatic phase, an overestimation that may arise in particular from a redistribution into the interstitial space. If ICG pulse spectrophotometry is used to measure functional hepatic reserve, the verified average difference from zero (1.55%/min) determined in our study needs to be taken into account.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research (discontinued)
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Brügger, Lukas; Studer, Peter; Schmid, Stefan; Pestel, Gunther Jürgen; Reichen, Jürg; Seiler, Christian; Candinas, Daniel and Inderbitzin, Daniel

ISSN:

1091-255X

ISBN:

17960466

Publisher:

Springer-Verlag

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:57

Last Modified:

26 Jun 2018 14:06

Publisher DOI:

10.1007/s11605-007-0352-3

PubMed ID:

17960466

Web of Science ID:

000252297100013

BORIS DOI:

10.7892/boris.24217

URI:

https://boris.unibe.ch/id/eprint/24217 (FactScience: 47665)

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