[Positive ibopamine provocative test in normal-tension glaucoma suspects]

Kniestedt, C; Romppainen, T; Gloor, B P; Stürmer, J (2007). [Positive ibopamine provocative test in normal-tension glaucoma suspects]. Klinische Monatsblätter für Augenheilkunde, 224(4), pp. 255-9. Stuttgart: Ferdinand Enke Verlag 10.1055/s-2007-962939

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BACKGROUND: Ibopamine is an alpha-adrenergic agent and causes an elevation of intraocular pressure in eyes with increased outflow resistance. It has been proposed as a test substance for the detection of early ocular hydrodynamic disorders. PATIENTS AND METHODS: A total of 64 normal-tension glaucoma suspect eyes without anti-hypertensive treatment were enrolled. A daily pressure curve was registered with measurements at 7:00 am, 8:00 am, 12:00 am, 17:00 pm using an applanation tonometer and a contour tonometer followed by instillation of ibopamine 2% in both eyes. Tonometry was performed every 15 minutes during the following hour. An IOP increase of > 2.0 mmHg was considered positive. RESULTS: The positive test group showed a significant pressure increase from 18.04 to 22.06 mmHg. Ocular pulse amplitude increased from 2.96 to 3.97 mmHg and was positively correlated with the pressure. Intraocular pressure was unchanged in the negative test group. Central corneal thickness was not significantly different in the two groups (p = 0.32). CONCLUSIONS: Ibopamine 2% eye drops have a positive pressure effect in 50% of suspected normal-tension glaucoma eyes and may differentiate between eyes with normal trabecular outflow capacity and eyes with increased resistance in the trabecular meshwork that are prone to pressure peaks and deterioration to glaucoma.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Gloor, Beat

ISSN:

0023-2165

ISBN:

17458787

Publisher:

Ferdinand Enke Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:57

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1055/s-2007-962939

PubMed ID:

17458787

Web of Science ID:

000246209700007

URI:

https://boris.unibe.ch/id/eprint/24234 (FactScience: 47737)

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