Stereoselective synthesis of a monocyclic peloruside a analogue

Wullschleger, Christoph W; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Stereoselective synthesis of a monocyclic peloruside a analogue. Organic letters, 12(5), pp. 1120-3. Washington, D.C.: American Chemical Society 10.1021/ol100123p

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The stereoselective synthesis of the monocyclic peloruside A analogue 4 has been achieved, following a new efficient approach for the introduction of the side chain, involving a late-stage addition of vinyl lithium species 7a to aldehyde 8. Further key steps are a highly diastereoselective allyltitanation reaction and a RCM-based macrocyclization.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Gertsch, Jürg

ISSN:

1523-7060

Publisher:

American Chemical Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

17 Mar 2015 19:14

Publisher DOI:

10.1021/ol100123p

PubMed ID:

20141163

Web of Science ID:

000274841800057

URI:

https://boris.unibe.ch/id/eprint/2444 (FactScience: 204943)

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