Visual and quantitative electroencephalographic analysis of healthy young and adult cats under medetomidine sedation

Wrzosek, Marcin; Nicpon, Jozef; Bergamasco, Luciana; Sammartano, Federica; Cizinauskas, Sigitas; Jaggy, André (2009). Visual and quantitative electroencephalographic analysis of healthy young and adult cats under medetomidine sedation. Veterinary journal, 180(2), pp. 221-230. Amsterdam: Elsevier 10.1016/j.tvjl.2007.11.003

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A study was designed to investigate the effect of medetomidine sedation on quantitative electroencephalography (q-EEG) in healthy young and adult cats to determine objective guidelines for diagnostic EEG recordings and interpretation. Preliminary visual examination of EEG recordings revealed high-voltage low-frequency background activity. Spindles, k-complexes and vertex sharp transients characteristic of sleep or sedation were superimposed on a low background activity. Neither paroxysmal activity nor EEG burst-suppression were observed. The spectral analysis of q-EEG included four parameters, namely, relative power (%), and mean, median and peak frequency (Hz) of all four frequency bands (delta, theta, alpha and beta). The findings showed a prevalence of slow delta and theta rhythms as opposed to fast alpha and beta rhythms in both young (group A) and adult (group B) cats. A posterior gradient was reported for the theta band and an anterior gradient for the alpha and beta bands in both groups, respectively. The relative power value in group B compared to group A was significantly higher for theta, alpha and beta bands, and lower for the delta band. The mean and median frequency values in group B was significantly higher for delta, theta and beta bands and lower for the alpha band. The study has shown that a medetomidine sedation protocol for feline EEG may offer a method for investigating bio-electrical cortical activity. The use of q-EEG analysis showed a decrease in high frequency bands and increased activity of the low frequency band in healthy cats under medetomidine sedation.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology

UniBE Contributor:

Jaggy, André








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Date Deposited:

04 Oct 2013 14:57

Last Modified:

21 Jan 2014 15:05

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URI: (FactScience: 51132)

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