Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women

Mellen, P B; Bittner, V; Herrington, D M (2007). Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women. Diabetic medicine, 24(10), pp. 1156-9. Chichester: Wiley 10.1111/j.1464-5491.2007.02222.x

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AIMS: We sought to determine whether fasting or post-challenge glucose were associated with progression of coronary atherosclerosis in non-diabetic women. METHODS: We performed a post-hoc analysis of 132 non-diabetic women who underwent 75-g oral glucose tolerance testing. The primary outcome of interest was progression of atherosclerosis determined by baseline and follow-up coronary angiography, a mean of 3.1 +/- 0.9 years apart. We analysed the association of change in minimal vessel diameter (DeltaMD) by quartile of fasting and post-challenge glucose using mixed models that included adjustment for age, systolic blood pressure, total : high-density lipoprotein cholesterol ratio, current smoking, lipid-lowering and anti-hypertensive medication use and other covariates. RESULTS: At baseline, participants had a mean age of 65.7 +/- 6.7 years and a mean body mass index of 27.9 +/- 8.5 kg/m(2). Although there were no significant differences in atherosclerotic progression by fasting glucose category (P for trend across quartiles = 0.99), there was a significant inverse association between post-challenge glucose and DeltaMD (in mm) (Q1 : 0.01 +/- 0.03; Q2 : 0.08 +/- 0.03; Q3 : 0.13 +/- 0.03; Q4 : 0.11 +/- 0.03; P for trend = 0.02). CONCLUSIONS: In post-menopausal women without diabetes, post-challenge glucose predicts angiographic disease progression. These findings suggest that even modest post-challenge hyperglycaemia influences the pathogenesis of atherosclerotic progression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Bittner, Vladimir

ISSN:

0742-3071

ISBN:

17672859

Publisher:

Wiley

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:57

Last Modified:

23 Jan 2018 12:17

Publisher DOI:

10.1111/j.1464-5491.2007.02222.x

PubMed ID:

17672859

Web of Science ID:

000249660600018

URI:

https://boris.unibe.ch/id/eprint/24554 (FactScience: 51493)

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