Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery disease

Vaidya, Dhananjay; Kelemen, Mark D; Bittner, Vera; Tardif, Jean-Claude; Thompson, Paul; Ouyang, Pamela (2007). Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery disease. Journal of women's health, 16(2), pp. 228-34. Larchmont, N.Y.: Mary Ann Liebert 10.1089/jwh.2006.0107

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BACKGROUND: We studied the association of baseline fasting plasma glucose (FPG) levels with survival and coronary artery disease (CAD) progression among postmenopausal women without unstable angina. METHODS: Women were recruited from seven centers in the Women's Angiographic Vitamin and Estrogen Trial (WAVE) (n = 423). Event follow-up was available for 400 women (65.1 +/- 8.5 years, 66% white, 92% hypertensive, 19% smokers, 67% hypercholesterolemic). Thirty-eight percent of the women had diabetes or FPG > 125 mg/dL, and 21% had a fasting glucose 100-125 mg/dL. Follow-up angiography was performed in 304 women. Cox regression was used to model survival from a composite outcome of death or myocardial infarction (D/MI, 26 events; median follow-up 2.4 years). Angiographic progression was analyzed quantitatively using linear regression accounting for baseline minimum lumen diameter (MLD), follow-up time, and intrasubject correlations using generalized estimating equations. Regression analyses were adjusted for follow-up time, baseline age, treatment assignment, and Framingham risk (excluding diabetes). RESULTS: Women with impaired fasting glucose/diabetes mellitus (IFG/DM) had a relative risk (RR) of D/MI of 4.2 ( p = 0.009). In all women, each 10 mg/dL increase in FPG was associated with an 11% increase ( p < 0.001) in the hazard of D/MI. Each 10 mg/dL increase in FPG was associated with a 6.8 mum decrease in MLD over the follow-up period ( p = 0.005). CONCLUSIONS: Higher FPG is associated with increased risk of D/MI and greater narrowing of the coronary lumen in women with CAD. Aggressive monitoring of glucose levels may be beneficial for secondary CAD prevention.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Bittner, Vladimir

ISSN:

1540-9996

ISBN:

17388739

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:57

Last Modified:

23 Jan 2018 12:18

Publisher DOI:

10.1089/jwh.2006.0107

PubMed ID:

17388739

Web of Science ID:

000245598600009

URI:

https://boris.unibe.ch/id/eprint/24555 (FactScience: 51502)

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