Oxygen-sensitive 3He-MRI in bronchiolitis obliterans after lung transplantation

Gast, Klaus Kurt; Biedermann, Alexander; Herweling, Annette; Schreiber, Wolfgang Günter; Schmiedeskamp, Jörg; Mayer, Eckhard; Heussel, Claus Peter; Markstaller, Klaus; Kauczor, Hans-Ulrich; Eberle, Balthasar (2008). Oxygen-sensitive 3He-MRI in bronchiolitis obliterans after lung transplantation. European radiology, 18(3), pp. 530-7. Berlin: Springer 10.1007/s00330-007-0778-8

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Oxygen-sensitive 3He-MRI was studied for the detection of differences in intrapulmonary oxygen partial pressure (pO2) between patients with normal lung transplants and those with bronchiolitis obliterans syndrome (BOS). Using software developed in-house, oxygen-sensitive 3He-MRI datasets from patients with normal lung grafts (n = 8) and with BOS (n = 6) were evaluated quantitatively. Datasets were acqiured on a 1.5-T system using a spoiled gradient echo pulse sequence. Underlying diseases were pulmonary emphysema (n = 10 datasets) and fibrosis (n = 4). BOS status was verified by pulmonary function tests. Additionally, 3He-MRI was assessed blindedly for ventilation defects. Median intrapulmonary pO2 in patients with normal lung grafts was 146 mbar compared with 108 mbar in patients with BOS. Homogeneity of pO2 distribution was greater in normal grafts (standard deviation pO2 34 versus 43 mbar). Median oxygen decrease rate during breath hold was higher in unaffected patients (-1.75 mbar/s versus -0.38 mbar/s). Normal grafts showed fewer ventilation defects (5% versus 28%, medians). Oxygen-sensitive 3He-MRI appears capable of demonstrating differences of intrapulmonary pO2 between normal lung grafts and grafts affected by BOS. Oxygen-sensitive 3He-MRI may add helpful regional information to other diagnostic techniques for the assessment and follow-up of lung transplant recipients.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Markstaller, Klaus Michael and Eberle, Balthasar










Jeannie Wurz

Date Deposited:

04 Oct 2013 14:57

Last Modified:

23 Jan 2018 12:17

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PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/24560 (FactScience: 51515)

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