Subcutaneous oxygen pressure in spontaneously breathing lean and obese volunteers: a pilot study

Hiltebrand, Luzius B; Kaiser, Heiko A; Niedhart, Dagmar J; Pestel, Gunther; Kurz, Andrea (2008). Subcutaneous oxygen pressure in spontaneously breathing lean and obese volunteers: a pilot study. Obesity surgery, 18(1), pp. 77-83. New York, N.Y.: Springer 10.1007/s11695-007-9313-x

Full text not available from this repository. (Request a copy)

BACKGROUND: Oxidative killing is the primary defense against surgical pathogens; risk of infection is inversely related to tissue oxygenation. Subcutaneous tissue oxygenation in obese patients is significantly less than in lean patients during general anesthesia. However, it remains unknown whether reduced intraoperative tissue oxygenation in obese patients results from obesity per se or from a combination of anesthesia and surgery. In a pilot study, we tested the hypothesis that tissue oxygenation is reduced in spontaneously breathing, unanesthetized obese volunteers. METHODS: Seven lean volunteers with a body mass index (BMI) of 22 +/- 2 kg/m(2) were compared to seven volunteers with a BMI of 46 +/- 4 kg/m(2). Volunteers were subjected to the following oxygen challenges: (1) room air; (2) 2 l/min oxygen via nasal prongs, (3) 6 l/min oxygen through a rebreathing face mask; (4) oxygen as needed to achieve an arterial oxygen pressure (arterial pO(2)) of 200 mmHg; and (5) oxygen as needed to achieve an arterial pO(2) of 300 mmHg. The oxygen challenges were randomized. Arterial pO(2) was measured with a continuous intraarterial blood gas analyzer (Paratrend 7); deltoid subcutaneous tissue oxygenation was measured with a polarographic microoxygen sensor (Licox). RESULTS: Subcutaneous tissue oxygenation was similar in lean and obese volunteers: (1) room air, 52 +/- 10 vs 58 +/- 8 mmHg; (2) 2 l/min, 77 +/- 25 vs 79 +/- 24 mmHg; (3) 6 l/min, 125 +/- 43 vs 121 +/- 25 mmHg; (4) arterial pO(2) = 200 mmHg, 115 +/- 42 vs 144 +/- 23 mmHg; (5) arterial pO(2) = 300 mmHg, 145 +/- 41 vs 154 +/- 32 mmHg. CONCLUSION: In this pilot study, we could not identify significant differences in deltoid subcutaneous tissue oxygen pressure between lean and morbidly obese volunteers.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Hiltebrand, Luzius; Kaiser, Heiko Andreas; Kaiser Niedhart, Dagmar Julika; Pestel, Gunther Jürgen and Kurz, Andrea

ISSN:

0960-8923

ISBN:

18064525

Publisher:

Springer

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:57

Last Modified:

23 Jan 2018 12:17

Publisher DOI:

10.1007/s11695-007-9313-x

PubMed ID:

18064525

Web of Science ID:

000252970200014

URI:

https://boris.unibe.ch/id/eprint/24561 (FactScience: 51520)

Actions (login required)

Edit item Edit item
Provide Feedback