Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study

Kimberger, Oliver; Ali, Syed Z; Markstaller, Monica; Zmoos, Sandra; Lauber, Rolf; Hunkeler, Corinne; Kurz, Andrea (2007). Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. Critical care, 11(1), R29. London: BioMed Central 10.1186/cc5709

[img]
Preview
Text
4.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (175kB) | Preview

INTRODUCTION: Mild therapeutic hypothermia has been shown to improve outcome for patients after cardiac arrest and may be beneficial for ischaemic stroke and myocardial ischaemia patients. However, in the awake patient, even a small decrease of core temperature provokes vigorous autonomic reactions-vasoconstriction and shivering-which both inhibit efficient core cooling. Meperidine and skin warming each linearly lower vasoconstriction and shivering thresholds. We tested whether a combination of skin warming and a medium dose of meperidine additively would reduce the shivering threshold to below 34 degrees C without producing significant sedation or respiratory depression. METHODS: Eight healthy volunteers participated on four study days: (1) control, (2) skin warming (with forced air and warming mattress), (3) meperidine (target plasma level: 0.9 mug/ml), and (4) skin warming plus meperidine (target plasma level: 0.9 mug/ml). Volunteers were cooled with 4 degrees C cold Ringer lactate infused over a central venous catheter (rate asymptotically equal to 2.4 degrees C/hour core temperature drop). Shivering threshold was identified by an increase of oxygen consumption (+20% of baseline). Sedation was assessed with the Observer's Assessment of Alertness/Sedation scale. RESULTS: Control shivering threshold was 35.5 degrees C +/- 0.2 degrees C. Skin warming reduced the shivering threshold to 34.9 degrees C +/- 0.5 degrees C (p = 0.01). Meperidine reduced the shivering threshold to 34.2 degrees C +/- 0.3 degrees C (p < 0.01). The combination of meperidine and skin warming reduced the shivering threshold to 33.8 degrees C +/- 0.2 degrees C (p < 0.01). There were no synergistic or antagonistic effects of meperidine and skin warming (p = 0.59). Only very mild sedation occurred on meperidine days. CONCLUSION: A combination of meperidine and skin surface warming reduced the shivering threshold to 33.8 degrees C +/- 0.2 degrees C via an additive interaction and produced only very mild sedation and no respiratory toxicity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Kimberger, Oliver; Ali, Syed Z.; Markstaller, Monica; Lauber, Rolf; Hunkeler, Corinne and Kurz, Andrea

ISSN:

1364-8535

ISBN:

17316456

Publisher:

BioMed Central

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:57

Last Modified:

23 Jan 2018 12:17

Publisher DOI:

10.1186/cc5709

PubMed ID:

17316456

Web of Science ID:

000247721000029

BORIS DOI:

10.7892/boris.24564

URI:

https://boris.unibe.ch/id/eprint/24564 (FactScience: 51531)

Actions (login required)

Edit item Edit item
Provide Feedback