Trypanosomes and mammalian sperm: one of a kind?

Oberholzer, Michael; Bregy, Patrick; Marti, Gabriela; Minca, Mihaela; Peier, Mihaela; Seebeck, Thomas (2007). Trypanosomes and mammalian sperm: one of a kind? Trends in parasitology, 23(2), pp. 71-7. Oxford: Elsevier Current Trends 10.1016/

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Flagellar-mediated motility is an indispensable function for cell types as evolutionarily distant as mammalian sperm and kinetoplastid parasites, a large group of flagellated protozoa that includes several important human pathogens. Despite the obvious importance of flagellar motility, little is known about the signalling processes that direct the frequency and wave shape of the flagellar beat, or those that provide the motile cell with the necessary environmental cues that enable it to aim its movement. Similarly, the energetics of the flagellar beat and the problem of a sufficient ATP supply along the entire length of the beating flagellum remain to be explored. Recent proteome projects studying the flagella of mammalian sperm and kinetoplastid parasites have provided important information and have indicated a surprising degree of similarities between the flagella of these two cell types.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Seebeck, Thomas




Elsevier Current Trends




Factscience Import

Date Deposited:

04 Oct 2013 14:57

Last Modified:

06 Dec 2013 13:49

Publisher DOI:


Web of Science ID:


URI: (FactScience: 52822)

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