Percutaneous technique for creation of tricuspid regurgitation in an ovine model

Hoppe, Hanno; Pavcnik, Dusan; Chuter, Tim A; Tseng, Elaine; Kim, Man Deuk; Bernat, Ivo; Uchida, Barry; Keller, Frederick S; Rösch, Josef (2007). Percutaneous technique for creation of tricuspid regurgitation in an ovine model. Journal of vascular and interventional radiology, 18(1 Pt 1), pp. 133-6. New York, N.Y.: Elsevier 10.1016/j.jvir.2006.10.009

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Experimental models of tricuspid regurgitation (TR) are needed to study the percutaneous placement of prosthetic atrioventricular valves. The purpose of this study was to develop an appropriate simple and reproducible percutaneous experimental model for creation of tricuspid regurgitation. Tricuspid regurgitation was successfully created through papillary muscle avulsion using a guide-wire loop in seven sheep with regurgitation documented on right ventricular angiograms and a significant increase in heart rate and right atrial pressures. Acute onset of tricuspid regurgitation was poorly tolerated in one animal that died. Autopsy examinations showed avulsion of one papillary muscle in four animals and two papillary muscles in three animals.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
UniBE Contributor:	Hoppe, Hanno
ISSN:	1051-0443
ISBN:	17296714
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:58
Last Modified:	05 Dec 2022 14:18
Publisher DOI:	10.1016/j.jvir.2006.10.009
PubMed ID:	17296714
Web of Science ID:	000244299200017
URI:	https://boris.unibe.ch/id/eprint/24987 (FactScience: 54378)