Upregulation of endothelin converting enzyme-1 in host liver during chronic cardiac allograft rejection

Lattmann, Thomas; Ortmann, Jana; Horber, Sibylle; Shaw, Sidney G; Hein, Marc; Barton, Matthias (2006). Upregulation of endothelin converting enzyme-1 in host liver during chronic cardiac allograft rejection. Experimental biology and medicine, 231(6), 899-901.. Maywood, N.J.: Society for Experimental Biology & Medicine

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Endothelin regulates cytokine expression in vitro and in vivo. This study investigated the effects of chronic allograft rejection on hepatic endothelin-converting enzyme-1 (ECE-1) gene expression and endothelin-1 (ET-1) plasma clearance. Using the Lewis-F344 minor histocompatibility mismatch model of heterotopic cardiac transplantation, hepatic ECE-1 gene expression was measured by real-time polymerase chain reaction and host plasma clearance of ET-1 was measured 8 weeks after transplantation in the absence of immunosuppression. In animals undergoing allograft rejection, hepatic ECE-1 gene expression increased 2-fold (P < 0.05), whereas no effect of rejection on ET-1 clearance from plasma was observed. In summary, upregulation of ECE-1 gene expression occurs in the liver of the host during chronic allograft rejection. Because the liver represents both a key organ for cytokine production and for endothelin metabolism, increased hepatic ECE-1-mediated ET-1 synthesis may contribute to host responses and cytokine production during allograft rejection.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Tiefenau Hospital [discontinued] > Forschungsgruppe Vasoaktive Peptide [discontinued]

UniBE Contributor:

Shaw, Sidney






Society for Experimental Biology & Medicine




Factscience Import

Date Deposited:

04 Oct 2013 14:58

Last Modified:

06 Dec 2013 13:49

PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/24997 (FactScience: 54597)

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