Contribution of the apparent diffusion coefficient in perilesional edema for the assessment of brain tumors

Guzman, R; Altrichter, S; El-Koussy, M; Gralla, J; Weis, J; Barth, A; Seiler, R W; Schroth, G; Lövblad, K O (2008). Contribution of the apparent diffusion coefficient in perilesional edema for the assessment of brain tumors. Journal of neuroradiology, 35(4), pp. 224-229. Issy-les-Moulineaux (F): Elsevier Masson 10.1016/j.neurad.2008.02.003

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OBJECTIVES: Diffusion-weighted MRI is sensitive to molecular motion and has been applied to the diagnosis of stroke. Our intention was to investigate its usefulness in patients with brain tumor and, in particular, in the perilesional edema. METHODS: We performed MRI of the brain, including diffusion-weighted imaging and mapping of the apparent diffusion coefficient (ADC), in 16 patients with brain tumors (glioblastomas, low-grade gliomas and metastases). ADC values were determined by the use of regions of interest positioned in areas of high signal intensities as seen on T2-weighted images and ADC maps. Measurements were taken in the tumor itself, in the area of perilesional edema and in the healthy contralateral brain. RESULTS: ADC mapping showed higher values of peritumoral edema in patients with glioblastoma (1.75 x 10(-3)mm(2)/s) and metastatic lesions (1.61 x 10(-3)mm(2)/s) compared with those who had low-grade glioma (1.40 x10(-3)mm(2)/s). The higher ADC values in the peritumoral zone were associated with lower ADC values in the tumor itself. CONCLUSIONS: The higher ADC values in the more malignant tumors probably reflect vasogenic edema, thereby allowing their differentiation from other lesions.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

El-Koussy, Marwan; Gralla, Jan and Schroth, Gerhard






Elsevier Masson




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Date Deposited:

04 Oct 2013 14:59

Last Modified:

08 Jun 2016 10:44

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URI: (FactScience: 58573)

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